Long Term Potentiation: How your brain learns - signalling pathway in synapse
LTP is a key process underlying learning and memory. It involves the strengthening of synaptic connections through repeated stimulation, allowing neurons to communicate more effectively. This phenomenon is primarily mediated by NMDA (N-methyl-D-aspartate) glutamate receptors and other molecular mechanisms. Role of NMDA and AMPA Receptors Glutamate , the major excitatory neurotransmitter in the CNS, plays a critical role in synaptic transmission. It binds to two key receptors: AMPA Receptors : Ionotropic receptors that allow Na + and K + ions to pass when activated, leading to fast excitatory synaptic transmission . NMDA Receptors : Normally blocked by Mg 2+ ions, preventing ion flow. Definition: In this context, sensitivity refers to for the same amount of stimulation (AP to CA3), the response (AP of CA1) is greater. Phases of LTP A. Normal Synaptic Transmission (Before LTP) ...