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Long Term Potentiation: How your brain learns - signalling pathway in synapse

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LTP is a key process underlying learning and memory. It involves the strengthening of synaptic connections through repeated stimulation, allowing neurons to communicate more effectively. This phenomenon is primarily mediated by NMDA (N-methyl-D-aspartate) glutamate receptors and other molecular mechanisms. Role of NMDA and AMPA Receptors Glutamate , the major excitatory neurotransmitter in the CNS, plays a critical role in synaptic transmission. It binds to two key receptors: AMPA Receptors : Ionotropic receptors that allow Na + and K + ions to pass when activated, leading to fast excitatory synaptic transmission . NMDA Receptors : Normally blocked by Mg 2+ ions, preventing ion flow. Definition: In this context, sensitivity refers to for the same amount of stimulation (AP to CA3), the response (AP of CA1) is greater. Phases of LTP A. Normal Synaptic Transmission (Before LTP) ...
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Short Base Pn Junction Diode Total Current Density Equation in steady state

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Now consider when voltage \( V_D \) is applied to the diode. Consider the forward biased case and observe the following figure the linear profile will be explained in the next section Recall from previously due to minority carrier injection into the QNR(outside the depletion region) \( n_p(-x_p)\gg n_{po}(-x_{po})=n_{po} \) \( p_n(x_n)\gg p_{no}(x_{no})=p_{no} \) This is essentially the concentration difference that drives the net diffusion into the QNR. See below for more Boundary Conditions Note that at the ohmic contacts in this figure we ensure that \( p_n(W_n)=p_{no} \) \( n_p(-W_p)=n_{po} \) that is the minority carrier concentrations are at their thermal equilibrium concentrations. Essentially we are saying that all excess carries injected starting from the edge of SCR must all recombine at the ohmic contact after diffusing across the negative concentration gradient assuming the balance between the very large ...
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